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| Biomedical Engineering | |
| BME 1501 | Special Topics (1) |
| Student led special topic courses which vary by semester Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Spring 2017, Fall 2016, Spring 2016, Fall 2015 | |
| BME 2000 | Biomedical Engineering Design and Discovery (3) |
| Offered Spring 2025 | Provides students with the skills necessary to engage in meaningful engineering design, and focuses on the latter stages of the engineering design process - detailed design, prototyping, and evaluation. Students develop skills in computer assisted design, embedded controls, prototyping, analysis and teamwork. A major focus of the class is the execution of a design project. Prerequisites: PHYS 1425, and BME major or minor. Recommended Corequisite: PHYS 2415 or ECE 2200. Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011, Fall 2009 |
| BME 2101 | Physiology I for Engineers (3) |
| Offered Spring 2025 | You will learn how excitable tissue, nerves and muscle, and the cardiovascular and respiratory systems function. You will develop an understanding of mechanisms, with an introduction to structure, an emphasis on quantitative analysis, and integration of hormonal and neural regulation and control. Prerequisites: (PHYS 1425 or PHYS 1420 or PHYS 1710) AND (APMA 1110 or MATH 1320) AND (CHEM 1410 or CHEM 1610 or CHEM 1810) AND BME Major or Minor Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Fall 2016, Fall 2015, Fall 2014, Fall 2013, Fall 2012, Fall 2011, Fall 2010, Fall 2009 |
| BME 2102 | Physiology II (3) |
| Offered Spring 2025 | Introduces the physiology of the kidney, salt and water balance, gastrointestinal system, endocrine system, and central nervous system, with reference to diseases and their pathophysiology. Prerequisite: (CHEM 1410 or CHEM 1610 or CHEM 1810) AND (PHYS 1425 or PHYS 1420 or PHYS 1710) AND BME 2101, or instructor permission. Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Spring 2019, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011, Spring 2010 |
| BME 2104 | Cell and Molecular Biology for Engineers (3) |
| Offered Spring 2025 | Intro to fundamentals of cell structure and function, emphasizing the techniques and technologies available for the study of cell biology. Content includes cell structure and function; energy flow in cells; information flow in cells focuses on modern molecular biology and genetic engineering, and includes DNA replication, the cell cycle, gene expression, gene regulation, and protein synthesis. Prerequisite: CHEM 1410 or CHEM 1610 or CHEM 1810 or instructor permission. Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011, Spring 2010 |
| BME 2220 | Biomechanics (3) |
| Offered Spring 2025 | Introduces principles of continuum mechanics of biological tissues & systems. 1) Review results used in biomechanics field, 2) properties of living tissue; 3) mechanical basis & effects of pathology & trauma: 4) intro to mechanotransduction, circulatory transport, growth & remodeling & tissue-engineered materials; 5) low Reynolds number flows in vivo & microsystems. Prerequisites: APMA 2120 or MATH 2310 or MATH 2315 and BME Major or Minor Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011, Spring 2010 |
| BME 2315 | Computational Biomedical Engineering (3) |
| Offered Spring 2025 | Introduces techniques for constructing predictive or analytical engineering models for biological processes. Teaches modeling approaches using example problems in transport, mechanics, bioelectricity, molecular dynamics, tissue assembly & imaging. Problem sets include 1) linear systems and filtering 2) compartmental modeling 3) numerical techniques 4) finite element / finite difference models and 5) computational automata models. Prereq: CS 1110 or CS 1111 or CS 1112. Co-requisites: APMA 2130 or MATH 3250 or APMA 2501- Differential Equations & Linear Algebra or instructor permission. Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Fall 2016, Fall 2015, Fall 2014 |
| BME 3030 | Design and Innovation in Medicine (3) |
| Offered Spring 2025 | Project-driven course focusing on biomedical product design with emphasis on marketability, innovation, entrepreneurship and business. Topics include design fundamentals, problem/needs identification, delineation of realistic constraints and product specifications, intellectual property, market analysis, entrepreneurship, specific advanced design, business plan development, venture funding, and medical product testing methods. Pre-requisite: BME 2000 or instructor permission. Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Spring 2020, Spring 2019, Spring 2018, January 2018, Spring 2017, January 2017, Spring 2016, January 2016 |
| BME 3040 | Regulation & Design of Biomedical Products (3) |
| The focus for the course will be establishing a regulatory mindset for students to engage with the Food & Drug Administration, primarily the Center for Medical Devices and Radiological Health. The material covered throughout the semester is presented in a series of lectures, design prompts, exercises, workshops, and reviews. Students will develop their own project(s) and work as individuals and in small groups/teams. Prereq: BME 2000 and BME 2101 | |
| BME 3080 | Biomedical Engineering Integrated Design and Experimental Analysis (IDEAS) (4) |
| A year-long course integrating concepts and skills from prior courses to formulate and solve problems in biomedical systems, including experimental design, performance and analysis. Testing in tissues/cells & manipulation of molecular constituents to determine structural and functional characteristics for design of therapeutic or measurement systems. Methods incl biochemical, physiological, cell biology, mechanical, electrical and computer, systems, chemical, imaging, and other approaches. Prerequisite: 3rd and 4th Year standing in Biomedical Engineering major Course was offered Fall 2024, Summer 2024, Fall 2023, Summer 2023, Fall 2022, Summer 2022, Fall 2021, Summer 2021, Fall 2020, Summer 2020, Fall 2019, Summer 2019, Fall 2018, Summer 2018, Fall 2017, Summer 2017, Fall 2016, Summer 2016, Fall 2015, Summer 2015, Fall 2014, Summer 2014, Fall 2013, Fall 2012, Fall 2011, Fall 2010, Fall 2009 | |
| BME 3090 | Biomedical Engineering Integrated Design and Experimental Analysis (IDEAS) (4) |
| Offered Spring 2025 | Second part of a year-long course integrating concepts and skills from prior courses to formulate and solve problems in biomedical systems, including experimental design, performance and analysis. Prerequisite: 3rd Year standing in BME major, or instructor permission Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Spring 2020, Spring 2019, Spring 2018, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011, Spring 2010 |
| BME 3240 | Biotransport (3) |
| Offered Spring 2025 | Introduces principles and application of fluid and mass transport processes in cell, tissue and organ systems. Topics include intro to physiological fluid mechanics in the circulation and tissue, fundamentals of mass transport in biological systems, effects of mass transport and biochemical interactions at the cell and tissue scales and fluid and mass transport in organs. Prerequisites: APMA 2130 or MATH 3250, or APMA 2501 - Differential Equations & Linear Algebra, and BME 2101, and BME 2104, or instructor permission. Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Spring 2017, Summer 2016, Spring 2016, Summer 2015, Spring 2015 |
| BME 3310 | Biomedical Systems Analysis and Design (3) |
| Offered Spring 2025 | Presents analytical tools used to model signals & linear systems. BME examples include multicompartment modeling of drug delivery, modeling of dynamic biomechanical systems & electrical circuit models of excitable cells. Topics: signals & systems, convolution, continuous time Fourier transforms, electrical circuits & applications of linear system theory. Prerequisite: PHYS 2415 & APMA 2130, & CS 1110 or equivalent Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Fall 2016, Fall 2015, Fall 2014, Fall 2013, Fall 2012, Fall 2011, Fall 2010, Fall 2009 |
| BME 3636 | Neural Network Models of Cognition and Brain Computation (3) |
| An introductory course to neural networks research, specifically biologically-based networks that reproduce cognitive phenomena. The goal of this course is to teach the basic thinking and methodologies used in constructing and understanding neural-like networks. Cross-listed as NESC 5330. 3rd or 4th year standing; or permission of the instructor. Course was offered Spring 2023, Spring 2022, Spring 2021, Spring 2020, Spring 2019, Spring 2018, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011, Spring 2010 | |
| BME 4063 | Biomedical Engineering Capstone Design I (3) |
| A year-long design project required for BME majors. Students select, formulate, and solve a design problem related to a device or a system. Projects use conceptual design, skills obtained in the integrated lab and substantial literature and patent reviews. Projects are sponsored by faculty, physicians and/or companies. Students may work on their own with outside team members when appropriate or with other students in integrative teams. Prerequisite: 4th year standing in the Biomedical Engineering major or instructor permission. | |
| BME 4064 | Biomedical Engineering Capstone Design II (3) |
| Offered Spring 2025 | Second half of a year-long design project required for BME majors. Students select, formulate, & solve a design problem related to a device or a system. Projects use conceptual design, skills obtained in the integrated lab & substantial literature and patent reviews. Projects are sponsored by faculty, physicians and/or companies. Students may work on their own with outside team members when appropriate or with other students in integrative teams. Prerequisite: 4th year standing in the Biomedical Engineering major or instructor permission. Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Spring 2020, Spring 2019, Spring 2018, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Fall 2011, Spring 2011, Fall 2010, Spring 2010 |
| BME 4280 | Motion Biomechanics (3) |
| Focuses on the study of forces (and their effects) that act on the musculoskeletal structures of the human body. Based on the foundations of functional anatomy and engineering mechanics (rigid body and deformable approaches); students are exposed to clinical problems in orthopedics and rehabilitation. Prerequisite: BME 2101 & BME 2220, or instructor permission. Course was offered Spring 2022, Fall 2019, Spring 2018, Spring 2016, Spring 2015, Spring 2014, Fall 2012, Fall 2011, Fall 2009 | |
| BME 4290 | Stem Cell Engineering (3) |
| How does a single fertilized egg grow and divide into every cell in the body, from branching neurons to beating cardiomyocytes and everything in between? Can we harness this knowledge to better understand disease, and to produce therapeutically relevant cell types, tissues, and organs? You will explore what controls stem cell differentiation using hands-on experiments, with emphasis on methods to engineer cell fate for regenerative medicine. Prerequisite: BME 2104 | |
| BME 4315 | Systems Bioengineering (3) |
| Offered Spring 2025 | This course introduces techniques for constructing mathematical and computational models of biological processes and utilizing experimental data to validate those models at many levels of organizational scale -- from genome to whole-tissue. Prerequisites: APMA 2130 or MATH 3250 or APMA 2501 - Differential Equations & Linear Algebra, and APMA 3110 or APMA 3100 or MATH 3100, and BME 2101, and BME 2104, and BME 2315 and BME major or minors Course was offered Spring 2023, Spring 2022 |
| BME 4350 | Biomedical Engineering Data Science (3) |
| Introduces genomics and bioinformatics theory and tools to analyze large scale biological data. Specific topics covered are Introduction to Linux and R statistical programming language, computations on the high-performance computational cluster, analysis of sequencing data with applications in gene expression and protein/DNA interactions, differential expression analysis, pathway and co-expression network analysis. Prereq: (APMA 3110 or APMA 3100 or MATH 3100) and (CS 1110 or CS 1111 or CS 1112 with grade of C- or better or successfully completed CS 1110 place-out test) and BME major or minor | |
| BME 4360 | Molecular Data Science (3) |
| Intro to systems-level measurement techniques for capturing molecular information and the mathematical and computational methods for harnessing the information from these measurements to improve our understanding of cell physiology and disease. Practical implementation of the concepts in MATLAB or Python will be applied to existing, real data from published journal articles. Pre-requisites: APMA 3100 or APMA 3110, BME 2104, BME 2315, and CS 1110 or CS 1111 or CS 1112 Course was offered Spring 2024 | |
| BME 4370 | Quantitative Biological Reasoning (3) |
| Offered Spring 2025 | This course will provide students with a quantitative framework for identifying and addressing important biological questions at the molecular, cell, and tissue levels. The course will focus on the interplay between methods and logic, with an emphasis on the themes that emerge repeatedly in quantitative experiments. |
| BME 4380 | Microbial Biomedical Engineering (3) |
| Offered Spring 2025 | "We will explore engineering methods to use ""microbes as tools"" for human wellbeing, to understand and combat ""microbes as enemies"" in infectious disease, and to characterize and manipulate ""microbes as partners"" in human health and wellbeing. We will learn how facets of BME are used to test hypotheses of human/microbe relationships and to design strategies to understand and treat disease and improve human wellbeing. Prerequisites: BME 2000 AND (BME 2101 OR BME 2102) AND BME 2104 AND BME 2315" Course was offered Spring 2024 |
| BME 4390 | Bioreaction Kinetics: Biomedical & Pharmacological Perspectives (3) |
| We will learn to bridge the gap between the fields of bioengineering and the science of how drugs interact with biological systems, i.e., Pharmacology, including the principles of biochemical reaction kinetics and engineering; how such principles can help us describe, model, predict and modulate the outcome of biochemical reactions in cells and biological reactors, and apply these principles to the understanding of pharmacological phenomena. Prerequisites: BME 2104 AND APMA 2130 Course was offered Fall 2024 | |
| BME 4414 | Biomaterials (3) |
| Introduces biomaterials science and biological interactions with materials with overview of biomaterials testing (in vitro and in vivo) and characterization. Emphasis on emerging novel strategies and design of biomaterials. Areas of concentration include polymers and ceramics in biomaterials, drug delivery, tissue engineering (orthopaedic and vascular) and nanotechnology. Prerequisite: BME 2101, BME 2104, or instructor permission. | |
| BME 4417 | Tissue Engineering (3) |
| Offered Spring 2025 | Introduces the fundamental principles of tissue engineering. Topics: tissue organization and dynamics, cell and tissue characterization, cell-matrix interactions, transport processes in engineered tissues, biomaterials and biological interfaces, stem cells and interacting cell fate processes and tissue engineering methods. Examples of approaches for regeneration of cartilage, bone, ligament, tendons, skin and liver are presented. Prerequisites: APMA 2130 or MATH 3250 or APMA 2501 - Differential Equations & Linear Algebra, and BME 2101, and BME 2104, or instructor permission. Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Spring 2020, Spring 2019, Spring 2017, Fall 2016, Spring 2015, Spring 2014, Spring 2011 |
| BME 4550 | Special Topics in Biomedical Engineering (1 - 3) |
| Offered Spring 2025 | Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester. Recent topics include Medical Imaging Systems Theory, BME Advanced Design, BME Electronics Lab, and Systems Biology Modeling and Experimentation. Prerequisite: third- or fourth-year standing or instructor permission. Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Spring 2017, Fall 2016, Spring 2016, Fall 2015, Spring 2015, January 2015, Fall 2014, Spring 2014, January 2014, Spring 2013, Fall 2012, Spring 2012, Fall 2011, Spring 2011, Fall 2010, Spring 2010, Fall 2009 |
| BME 4641 | Bioelectricity (3) |
| Studies the biophysical mechanisms governing production and transmission of bioelectric signals, measurement of these signals and their analysis in basic and clinical electrophysiology. Introduces the principles of design and operation of therapeutic medical devices used in the cardiovascular and nervous systems. Prerequisite: BME 2101 and (BME 3310 or ECE 2630 or ECE 2300) and BME major or minor, or instructor permission. | |
| BME 4783 | Medical Imaging Modalities (3) |
| An overview of modern medical imaging modalities with regard to the physical basis of image acquisition and methods of image reconstruction. Topics cover the basic engineering and physical principles underlying the major medical imaging modalities: x-ray (plain film, mammography, CT), nuclear medicine (PET) and (SPECT), ultrasound, and MRI. Prerequisite: BME 2315, BME 3310, or instructor permission. Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Spring 2020, Fall 2018, Spring 2018, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011 | |
| BME 4784 | Medical Image Analysis (4) |
| Introduces the fundamental principles of medical image analysis and visualization. Focuses on the processing and analysis of ultrasound, MR and X-ray images for quantitation and visualization to increase the usefulness of modern medical image data. Includes image perception and enhancement, 2-D Fourier transform, spatial filters, segmentation and pattern recognition. Prerequisite: BME 3310 or ECE 3750 or ECE 2700, and BME Major or Minor, or instructor permission. | |
| BME 4806 | Biomedical Applications of Genetic Engineering (3) |
| Provides a grounding in molecular biology and a working knowledge of recombinant DNA technology, thus establishing a basis for the evaluation and application of genetic engineering in whole animal systems. Beginning with the basic principles of genetics, this course examines the use of molecular methods to study gene expression, deliver viral and non-viral vectors, and its critical role in health. Prerequisite: BME 2101. Co-requisites: BME 2104. Course was offered Fall 2024, Fall 2023, Fall 2022, Fall 2021, Fall 2020, Fall 2019, Fall 2018, Fall 2017, Fall 2016, Fall 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011, Spring 2010 | |
| BME 4890 | Nanomedicine (3) |
| Students will design treatment strategies for cancer and cardiovascular disease based on molecular bioengineering principles. Special topics will include design of nanoparticle drug and gene delivery platforms, materials biocompatibility, cancer immunotherapy, and molecular imaging. Prerequisite: BME 2102 and BME 2315 or instructor permission. Recommended prerequisite: BME 2104 or BME 4414. Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Fall 2019, Fall 2018, Fall 2017, Fall 2016, Fall 2015, Fall 2014, Fall 2013, Fall 2012, Fall 2011, Fall 2010, Fall 2009 | |
| BME 4993 | Independent Study (1 - 3) |
| Offered Spring 2025 | In-depth study of a biomedical engineering area by an individual student in close collaboration with a departmental faculty member. Requires advanced analysis of a specialized topic in biomedical engineering that is not covered by current offerings. Requires faculty contact time and assignments comparable to regular course offerings. Prerequisite: instructor permission. Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Fall 2018, Spring 2018, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Fall 2013, Spring 2013, Fall 2012, Spring 2012, Spring 2011, Spring 2010, Fall 2009 |
| BME 4995 | Biomedical Engineering Advanced Projects (1 - 3) |
| Offered Spring 2025 | A year-long research project in biomedical engineering conducted in consultation with a department faculty advisor; usually related to ongoing faculty research. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Requires a comprehensive report of the results. Prerequisite: third- or fourth-year standing, and instructor permission. Course was offered Fall 2024, Summer 2024, Spring 2024, Fall 2023, Summer 2023, Spring 2023, Fall 2022, Summer 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Spring 2017, Fall 2016, Spring 2016, Fall 2015, Spring 2015, Fall 2014, Spring 2014, Fall 2013, Spring 2013, Fall 2012, Spring 2012, Fall 2011, Spring 2011, Fall 2010, Spring 2010, Fall 2009 |
| BME 6001 | Cell and Molecular Physiology for Engineers (2) |
| Students learn foundational concepts about cellular behaviors and the molecular mechanisms that drive them by communicating findings that are published in peer-reviewed scientific and engineering papers. Prereqs: coursework in Biochemistry, Cell Biology, Human Physiology/Pathology/Anatomy Course was offered Fall 2024 | |
| BME 6002 | Organ-Level Physiology for Engineers (2) |
| This course presents organ physiology and pathology as systems that can be studied, measured, and manipulated using biomedical engineering tools and approaches by reading peer-reviewed scientific and engineering papers and discussing them in class. Prereq: knowledge of Biochem, Cell Biology, Human Physiology/Pathology/Anatomy Course was offered Fall 2024 | |
| BME 6003 | Biostatistical Analysis and Experimental Design (2) |
| Students learn foundational principals of advanced research, including hypothesis formulation, experimental design, and statistical methods to assess experimental data as it relates to hypothesis testing. Prerequisites: Previous exposure to statistics and programming in a language such as Python, MATLAB, or R. Course was offered Fall 2024 | |
| BME 6004 | Signals and Systems Analysis for Biomedical Applications (2) |
| Students learn how to process imperfect biomedical measurements and extract information. Students learn fundamental principles of signal and image processing and machine learning. Prerequisites: Ability to program in MATLAB or Python. Knowledge of calculus, vectors and matrices Course was offered Fall 2024 | |
| BME 6005 | Research Fundamentals for Biomedical Engineers (2) |
| Offered Spring 2025 | Students learn to motivate research, design experiments, analyze/display data, present results for their own research. Receive training in professional skills, including project leadership and management, best practices for collaborative research, and developing resilience. Prereq: BME 6001-6004, or permission by instructor |
| BME 6006 | Biomedical Data Science and Analytics (2) |
| Offered Spring 2025 | Students learn principles and techniques to computationally approach biomedical research and practice. Students obtain hands-on experience using computational thinking/strategy and build computational models to describe biomedical phenomena or analyze biomedical data. Prereq: BME 6001-6004 and ability in MATLAB or Python. |
| BME 6026 | Quantitative Models of Human Perceptual Information Processing (3) |
| An introduction to the measurement and modeling of human perceptual information processing, with approaches from neurophysiology to psychophysics, for the purposes of system design. Measurement includes classical psychophysics, EEG field potentials, and single-neuron recordings. Modeling includes signal detection theory, neuronal models (leaky integrate-and-fire, Hodgkin-Huxley, and models utilizing regression, probability, and ODEs).
Prerequisite: Graduate standing; background courses in ordinary differential equations, statistics and probability; or consent of instructor. Course was offered Spring 2013 | |
| BME 6030 | Design and Innovation in Medicine (3) |
| Offered Spring 2025 | A project-based grounding in biomedical product design, with emphasis on clinical immersion and topics including design fundamentals, problem/needs identification, delineation of realistic constraints and product specifications, intellectual property, market analysis, entrepreneurship, specific advanced design topics, business plan development, venture funding, and medical product testing methods. Prerequisite: Instructor Permission Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Spring 2020, Spring 2019, Spring 2018, Spring 2017, Spring 2016 |
| BME 6056 | Going Pro, Professional Development in Biomedical Engineering (1 - 2) |
| Offered Spring 2025 | A professional development course for biomedical engineering graduate students. Course was offered Fall 2024, Spring 2024, Spring 2023, Fall 2021, Fall 2020, Fall 2019, Spring 2018 |
| BME 6060 | Biomedical Innovation (3) |
| Offered Spring 2025 | In a team, develop, prototype, and conduct verification and validation tests on engineering solutions to clinical challenges, demonstrating concept viability. Formal Design Control, Life Cycle, Risk Analysis, Project Management and Intellectual Property Strategies are introduced. Using Product Development Protocols, prepare a regulatory and implementation pathway analysis for commercialization into clinical practice. Prerequisite: BME 6550 Special Topics: Clinical Technology Continuum of Care |
| BME 6101 | Physiology I for Engineers (3) |
| Introduces fundamental concepts of cellular physiology; applies quantitative engineering analysis to intra- and intercellular signaling and mechanical systems relevant to organ physiology and pathology; teaches students to learn to think critically about the physiology and cell biology literature. Prerequisite: BME 2104 or equivalent; proficiency with ODEs. | |
| BME 6102 | Engineering Physiology II (3) |
| Second part of physiology sequence for engineering students; focuses on physiology of the cardiovascular, pulmonary, renal, and nervous systems; emphasizes quantitative analysis of organ function, particularly the use of mathematical models to identify and understand key underlying mechanisms. Prerequisite: BME 6101 Course was offered Spring 2021, Spring 2020, Spring 2019, Spring 2018, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2012, Spring 2011, Spring 2010 | |
| BME 6280 | Motion Biomechanics (3) |
| Focuses on the study of forces (and their effects) that act on the musculoskeletal structures of the human body. Based on the foundations of functional anatomy and engineering mechanics (rigid body and deformable approaches); students are exposed to clinical problems in orthopedics and rehabilitation. Cross-listed as AM 6280. Prerequisite: BME 6103. Course was offered Spring 2022, Fall 2019, Spring 2018, Spring 2016, Spring 2015, Spring 2014, Fall 2012, Fall 2011, Fall 2009 | |
| BME 6310 | Computation and Modeling in Biomedical Engineering (3) |
| The principle objective of this course is to instruct graduate students on fundamental mathematical, modeling, and computational principles of relevance in biomedical engineering. The course is structured to provide lecture material, biomedical examples that use modeling and computation, and homework/exams that strengthen the mathematical and computational foundation of the graduate students. Prerequisites: 1. BME 6101: Physiology I (or equivalent) 2. SEAS grad student status 3. Some previous exposure to probability-statistics, Fourier analysis, and linear systems 4. Or instructor permission | |
| BME 6311 | Research Fundamentals (3) |
| Students will gain a fundamental understanding of the theoretical principles underlying biomedical measurements. Topics are organized sequentially from signal initiation through signal processing to downstream statistical analysis of measurements. Students will be exposed to the practical implementation of general principles through homework assignments that involve the analysis and evaluation of molecular, cellular, and clinical measurements. Prerequisites: 1. BME 6101: Physiology I (or equivalent) 2. SEAS graduate student status 3. Some previous exposure to probability-statistics, Fourier analysis, and linear systems 4. Or Instructor Permission Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Spring 2020, Spring 2019, Spring 2018, Spring 2017, Spring 2016, Spring 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011 | |
| BME 6315 | Systems Bioengineering (3) |
| Offered Spring 2025 | Introduces techniques for constructing mathematical and computational models of biological processes at many levels of organizational scale from genome to whole-tissue. Topics include choice of techniques, quantitative characterization of biological properties, assumptions and model simplification, parameter estimation and sensitivity analysis, model verification and validation and integration of computational modeling w/experimental approaches.
Prerequisites: BME 6101, and BME 2104 or BME 7806 (or equivalent). |
| BME 6550 | Special Topics in Biomedical Engineering (1 - 3) |
| Offered Spring 2025 | Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester. Course was offered January 2025, Fall 2024, Spring 2024, Fall 2023, Summer 2023, Spring 2023, Fall 2022, Summer 2022, Spring 2022, Fall 2021, Summer 2021, Spring 2021, January 2021, Fall 2020, Summer 2020, Spring 2020, Fall 2019, Spring 2019, Fall 2018, Spring 2018, Fall 2017, Spring 2017, Fall 2016, Spring 2016, Fall 2015, Fall 2014, Fall 2013, Spring 2013, Fall 2012, Fall 2011, Spring 2011, Fall 2010, Fall 2009 |
| BME 6705 | Recent Advances in Public Health Genomics (3) |
| Offered Spring 2025 | The course will cover human genetics and genomics, including the human/mammalian genome variation, determination of genomic variation on phenotype and disease risk, mapping and characterizing genetic variants on phenotype, determining the putative impact of genetic variants on gene expression (transcriptomics, epigenomics), the promise and implications of genome science on precision medicine and the ethical, legal & social implications.
Pre-requisite: BIOL 3010 or BIOL 4210 or instructor consent. Course was offered Spring 2023, Spring 2021 |
| BME 7370 | Quantitative Biological Reasonsing (3) |
| Offered Spring 2025 | Provides students with a quantitative framework for identifying and addressing important biological questions at the molecular, cell, and tissue levels. Focuses on the interplay between methods and logic, with an emphasis on the themes that emerge repeatedly in quantitative experiments. Prerequisites: BME 6101 (or equivalent), SEAS graduate student status, or instructor permission. Course was offered Spring 2024, Spring 2023, Spring 2022, Spring 2021, Spring 2020, Spring 2019, Spring 2018, Spring 2017, Spring 2015, Spring 2013, Spring 2011 |
| BME 7641 | Bioelectricity (3) |
| Studies the biophysical mechanisms governing production and transmission of bioelectric signals, measurement of these signals and their analysis in basic and clinical electrophysiology. Introduces the principles of design and operation of therapeutic medical devices used in the cardiovascular and nervous systems. Prerequisite: BME 6310 or instructor permission. | |
| BME 7782 | Medical Imaging Systems Theory (3) |
| Develops an intuitive understanding of the mathematical systems theory needed to understand and design biomedical imaging systems, including ultrasound, magnetic resonance imaging and computed tomography. Topics will include multidimensional Fourier transform theory, image reconstruction techniques, diffraction theory, and Fourier optics. Prerequisite: BME 6310 or equivalent exposure to linear systems theory or instructor permission. | |
| BME 7784 | Medical Image Analysis (3) |
| Comprehensive overview of medical image analysis and visualization. Focuses on the processing and analysis of these images for the purpose of quantitation and visualization to increase the usefulness of modern medical image data. Topics covered involve image formation and perception, enhancement and artifact reduction, tissue and structure segmentation, classification and 3-D visualization techniques as well as pictures archiving, communication and storage systems. Involves 'hands-on' experience with homework programming assignments. Prerequisite: BIOM 6310 and ECE 6782 or instructor permission. | |
| BME 7806 | Biomedical Applications of Genetic Engineering (3) |
| Provides biomedical engineers with a grounding in molecular biology and a working knowledge of recombinant DNA technology, thus establishing a basis for the evaluation and application of genetic engineering in whole animal systems. Beginning with the basic principles of genetics, this course examines the use of molecular methods to study gene expression and its critical role in health and disease. Topics include DNA replication, transcription, translation, recombinant DNA methodology, methods for analyzing gene expression (including microarray and genechip analysis), methods for creating genetically-engineered mice, and methods for accomplishing gene therapy by direct in vivo gene transfer. Prerequisite: BME 6103, undergraduate-level cell and/or molecular biology course. (e.g., BME 2104) or instructor permission. Suggested preparation: biochemistry, cell biology, genetics, and physiology.. Course was offered Fall 2024, Fall 2023, Fall 2022, Fall 2021, Fall 2020, Fall 2019, Fall 2018, Fall 2017, Fall 2016, Fall 2015, Spring 2014, Spring 2013, Spring 2012, Spring 2011, Spring 2010 | |
| BME 8000T | Non-UVa Transfer/Test Credit Approved (1 - 48) |
| Non-UVa Transfer/Test Credit Approved | |
| BME 8550 | Advanced Topics in Biomed Engineering (3) |
| Applies engineering science, design methods, and system analysis to developing areas and current problems in biomedical engineering. Topics vary by semester. | |
| BME 8730 | Diagnostic Ultrasound Imaging (3) |
| Underlying principles of array based ultrasound imaging. Physics and modeling techniques used in ultrasound transducers. Brief review of ID circuit transducer models. Use of Finite Element techniques in transducer design. Design considerations for 1.5D and 2D arrays will be reviewed. Diffraction and beamforming will be introduced starting from Huygen's principle. FIELD propagation model will form an important part of the class. In depth discussion of various beamforming and imaging issues such as sidelobes, apodization, grating lobes, resolution, contrast, etc. The course addresses attenuation, time-gain-compensation and refraction. Finally, speckle statistics and K-Space techniques will be introduced. Laboratories will involve measuring ultrasound image metrics, examining the effect of various beamforming parameters and simulating these on a computer using Matlab. Prerequisite: instructor permission, BIOM 6310 and BIOM 6311. Preparation: Undergraduate Physics, Electronic circuit analysis, Differential Equations, Fourier and Laplace Transforms, Sampling Theorems. | |
| BME 8782 | Magnetic Resonance Imaging (3) |
| The course covers the physical principles of nuclear magnetic resonance, the biological and medical problems addressed using MRI, the analysis and design of MRI pulse sequences from a signal processing perspective, and MR image reconstruction techniques. It will introduce various advanced topics, including non-Cartesian scanning and compressed sensing. The course will include a laboratory session working with an MRI scanner.
Prerequisites: BME 6311 BME Measurement Principles, or knowledge of 2D Fourier transforms and linear systems theory. | |
| BME 8783 | Advanced Magnetic Resonance Imaging (3) |
| Advanced physics and applications of magnetic resonance imaging and spectroscopy will be covered. Upon completion of this course, the student will understand the factors that affect the MRI signal, and will know how these factors can be exploited to image or measure various aspects of physiology with MR. Prerequisites: BME 8782 Magnetic Resonance Imaing and MATLAB experience. | |
| BME 8823 | Cell Mechanics, Adhesion, and Locomotion (3) |
| Biomechanics and structural biology of cell structure and function, focusing on quantitative description and measurements of cell deformability, adhesion, and locomotion. Cell deformability: erythrocyte properties, membrane mechanics, shear, bending, and area elasticity. Leukocyte structure and deformability. Structural basis of plasma membrane, lipid bilayer, surface structures, nucleus, organelles, cell junctions, cytoskeleton, membrane transport, active cytoskeletal functions, specific and non-specific forces between molecules, protein structure, molecular graphics. Cell adhesion molecules: families of adhesion molecules, cell-cell and cell-matrix binding, biochemical characteristics, regulation of expression, regulation of binding avidity, functional role. Cell adhesion assays: detachment assays, aggregation of leukocytes and platelets, controlled shear systems, flow chambers. Mechanics of cell adhesion: equilibrium analysis of cell adhesion, models of cell rolling, adhesion bond mechanics. Liposomes, microbubbles, and applications to targeted adhesion. Cell motility: measurement of active forces and motility in cells, molecular motors. Effects of mechanical stress and strain on cell function. Prerequisite: Instructor permission. Course was offered Fall 2009 | |
| BME 8890 | Biomolecular Engineering (3) |
| In this class, students design treatment strategies for cancer and cardiovascular disease based on molecular bioengineering principles. Special topics will include design of nanoparticle drug and gene delivery platforms, materials biocompatibility, cancer immunotherapy, and molecular imaging. Prerequisites: Undergraduate coursework in cell and molecular biology and biomechanics. Recommended undergraduate course in transport processes. | |
| BME 8900 | Graduate Teaching Instruction (1 - 6) |
| Offered Spring 2025 | For master's students. Course was offered Fall 2024, Spring 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Spring 2020, Fall 2019, Fall 2010, Spring 2010, Fall 2009 |
| BME 8995 | Supervised Project Research (GRAD STUDENTS ONLY) (1 - 6) |
| Offered Spring 2025 | FOR GRAD STUDENTS ONLY. A research project in biomedical engineering conducted in consultation with a faculty advisor. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Fulfills the project requirement for the Biomedical Engineering Masters of Engineering degree. Prereqs: Instructor Permission Required. Course was offered Fall 2024, Summer 2024, Spring 2024, January 2024, Fall 2023, Spring 2023, Fall 2022, Spring 2022, Fall 2021, Spring 2021, Fall 2020, Fall 2019, Summer 2019, Spring 2019, Summer 2018, Spring 2018, Fall 2017, Summer 2017, Spring 2017, Fall 2016, Summer 2016, Spring 2016, Fall 2015, Summer 2015, Spring 2015, Fall 2014, Summer 2014, Spring 2014, Fall 2013, Summer 2013, Spring 2013, Fall 2012, Summer 2012, Spring 2012, Fall 2011, Summer 2011, Spring 2011, Fall 2010, Summer 2010, Spring 2010, Fall 2009 |
| BME 8999 | Master's Research (1 - 12) |
| Offered Spring 2025 | Master's Research Course was offered Fall 2024, Summer 2024, Spring 2024, Fall 2023, Summer 2023, Spring 2023, Fall 2022, Summer 2022, Spring 2022, Fall 2021, Summer 2021, Spring 2021, Fall 2020, Summer 2020, Spring 2020, Fall 2019, Summer 2019, Spring 2019, Fall 2018, Summer 2018, Spring 2018, Fall 2017, Summer 2017, Spring 2017, Fall 2016, Summer 2016, Spring 2016, Fall 2015, Summer 2015, Spring 2015, Fall 2014, Summer 2014, Spring 2014, Fall 2013, Summer 2013, Spring 2013, Fall 2012, Summer 2012, Spring 2012, Fall 2011, Summer 2011, Spring 2011, Fall 2010, Summer 2010, Spring 2010, Fall 2009 |
| BME 9999 | Dissertation (1 - 12) |
| Offered Spring 2025 | Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary. Course was offered Fall 2024, Summer 2024, Spring 2024, Fall 2023, Summer 2023, Spring 2023, Fall 2022, Summer 2022, Spring 2022, Fall 2021, Summer 2021, Spring 2021, Fall 2020, Summer 2020, Spring 2020, Fall 2019, Summer 2019, Spring 2019, Fall 2018, Summer 2018, Spring 2018, Fall 2017, Summer 2017, Spring 2017, Fall 2016, Summer 2016, Spring 2016, Fall 2015, Summer 2015, Spring 2015, Fall 2014, Summer 2014, Spring 2014, Fall 2013, Summer 2013, Spring 2013, Fall 2012, Summer 2012, Spring 2012, Fall 2011, Summer 2011, Spring 2011, Fall 2010, Summer 2010, Spring 2010, Fall 2009 |